IUI

What is IUI?

IUI stands for Intrauterine Insemination, a kind of assisted conception treatment which involves the administration of injection of prepared sperm into the womb at the time of ovulation. The fertility drugs are given to stimulate egg production and ovulation, and to prepare the uterus to receive embryos.

The sperm used can be from your partner or a donor. The use of donor sperm is indicated in the following cases:

  • When there is a deficiency of sperm in the partner.
  • In the treatment of single women or lesbian couples
  • When there’s some hereditary disease in the male partner.

Typically four to six cycles of IUI are recommended – after this stage, alternative treatments are considered more appropriate.

Why is IUI treatment used?

IUI method is recommended in the following cases:

  • The couples that have unexplained infertility or very mild factors preventing natural pregnancy.
  • Mild endometriosis.
  • Single women Female same gender couples/lesbians.
  • When there is low sperm count.
  • When sperm mobility is poor.
  • The presence of cervical scar tissues from previous procedures.
  • When there’s ejaculation dysfunction and a hostile cervical condition.

What is the necessary treatment procedure?

IUI process involves the following steps:

  • A blood test and ultrasounds are done at the beginning of the menstrual cycle.
  • A prescription of fertility enhancing drugs is given to stimulate the ovaries.
  • To assess the readiness of follicles, additional scans are done.
  • Roughly 40 hours before insemination HCG injection is administered.
  • Semen is collected, which is then prepared in the laboratory and placed inside the uterus using a fine catheter.

Assisted Hatching

What is Assisted Hatching?

  • Assisted Hatching is a scientific technique practiced in In Vitro Fertilisation (IVF) that may enhance the implantation of embryos into a female’s uterine lining by creating an opening through, which the embryonic cells can hatch out.
  • It is used to assist the embryo hatch from its protective exterior shell, the zona pellucida, and promote implantation in the uterine wall following embryo transfer.

What is Laser Assisted Hatching?

  • Laser-assisted hatching (LAH) uses a highly focused infrared laser beam over the zona pellucida to make a small opening, between 10-20 microns to facilitate embryo hatching. LAH is done just before the Embryo Transfer.
  • LAH requires less handling of the embryo than any other assisted hatching methods.
  • It is faster than the other methods and, therefore, the embryo spends less time outside the incubator.
  • It improves implantation and helps strengthen the Pregnancy rates.

Which patients could benefit from this procedure?

The following patients can benefit from LAH:

  • Advanced maternal age (>37 years old).
  • Patients with elevated baseline level of follicle stimulating hormone (FSH).
  • Women with poor prognosis embryos, including conditions such as a thick zona pellucida, slow cell division rate, or high cell fragmentation
  • Poor quality/slow developing embryos.
  • Embryos are exhibiting excessive fragmentation.
  • Patient with two or more past failed IVF cycles.

What is the necessary treatment procedure?

LAH process involves the following steps:

  • Step 1: – On day three of embryo development, the embryologist uses either weak acid in a fine glass pipette, a microlaser or a micro tool to thin or cut a hole in the external layer of the embryo.
  • Step 2: – If weak acid was used, the embryo is washed to prevent further damage.
  • Step 3: – Because the assisted hatching thins the protective outer layer around the embryo or makes a hole in it, the woman may be given antibiotics to prevent infection.

SET

What is single embryo transfer (SET)?

  • Single-embryo transfer (SET) is a procedure in which one embryo, chosen from a larger number of available embryos, is planted in the uterus or fallopian tube.
  • The embryo selected for SET might be from a previous IVF cycle (cryopreserved embryos (frozen)) or from the fresh IVF cycle that yielded more than one embryo.
  • The remaining embryos may be set aside for future use or cryopreservation.
  • SET helps women avoid several risks to their health that are associated with carrying multiples.
  • It also helps families achieve success while preventing some risks known to be related to giving birth to twins or “high order multiple births.”
  • Infants born in multiple births are more often born early, are smaller (low birth weight) and experience more serious health outcomes than singleton infants.

FET

What is FET?

  • The FET stand for Frozen Embryo Transfer. You can transfer embryos that were frozen during a previous cycle to the womb.
  • FET drugs are used to prepare the uterus to receive the embryos. Your progress is monitored to assess the right time for the transfer, maximizing the chances of achieving a pregnancy.

Which patients could benefit from this procedure?

  • FET is appropriate if you have successfully fertilized embryos suitable for freezing, and wish to come back for more treatment without going through a full cycle of IVF.

PGD

What is PGD?

  • Preimplantation Genetic Diagnosis (PGD) is the name of a reproductive technology practiced with an IVF cycle.
  • PGD can be adopted for diagnosis of a genetic disease and to examine for specific serious hereditary disorders in early embryos before implantation and pregnancy.
  • Also, this technology can be utilized in the field of assisted reproduction for aneuploidy screening and examination of unbalanced inheritance of chromosome abnormalities, such as translocations or inversions.