Fertility clinics or ART centres use the term IVF success
rate to talk about how successful the treatment is for the couple. Couples look
at IVF success rate when they want to know how likely it will be to have a baby
when they start the treatment.
IVF success rates vary in very big ways.
In India, the success rate
of IVF ranges from 30% to 35%. Globally, the average IVF success rate is around
40% in young women.
There are many factors one should consider when it comes
to IVF success.
- Age of the female partner
- Duration of infertility
- Type of infertility (primary or secondary)
- Cause of infertility
- Quality of the gametes (sperm, egg, and embryo)
- Own oocyte/donor oocytes
- The endometrial development
- Luteal phase post transfer
- Use of techniques such as ICSI/PGS
- Fresh or frozen cycles embryo transfer
Age of Female
A woman’s age is the most important factor in determining
the success of IVF, if own eggs are to be used. Egg quality is best under the
age of 35 and success rates are maximum in young age.
After 35 years of age, female eggs are prone to making genetic
errors leading to defects in the off springs.As egg quality declines with age
and also the ovarian reserve (the number of eggs), the success rates of IVF
also decreases. Females under the age of 35almost
have a 50-50 chance of carrying a baby to term using IVF. However, the chance
of success is halved by the age of 40 and success rate after 42 years of age is
less than 5%. These numbers and trends concern women using their own eggs.
Number of embryos transfer
Rate of multiple births in IVF is high compared to a mere
1-2% in natural pregnancy. This is a result of transferring multiple
embryos in a woman’s uterus in the hope that at least one of them implants.
However, it turns out that transferring more than one
embryo does not increase the chance of pregnancy, rather is increases chances
of multiple pregnancies. In fact, the percentage of live birth rate decreases
significantly as the number of embryos transferred increases.
Fresh or frozen egg
transfer means implanting the embryos in the same cycle when stimulating the
ovaries to produce eggs. Frozen means when embryos had been frozen in a
previous cycle and transfer is planned in a subsequent cycle.
It is proven that frozen embryo transfers are
better as compared to fresh transfers when using your own eggs. This
superiority is thought to be due to ovarian stimulating hormones that render
the endometrium less receptive in the current cycle when the injectables are
Cause of infertility
are many different types of infertility problems, which affect both males and
females. They need to be treated differently, which are important in maximizing
Use of technologies (PGS and ICSI)
make a huge difference to the success rate in IVF cycles.
improves implantation rate by selectively transferring genetically normal
For couples with
male factor infertility, Intracytoplasmic sperm
injection (ICSI) helps
to deliver a sperm directly into the egg for its fertilization.
Day of embryo transfer
3 and day 5 embryo transfers are the most commonly used, but day 5 (blastocyst)
transfer offers a 10% higher success rate.
Competency of the clinic
rate of any particular infertility centre depends on its technology, staff experience and protocols
Donor eggs and Surrogacy
eggs are recommended to women of advanced maternal age, females of premature
ovarian failure and who have a severe genetic problem that can be transmitted
to future generations. However, these are also indicated for patients who have
severely damaged egg quality, such as due to cancer treatment.
is an option to avoid miscarriages, pregnancy complications and improve success
rates in women who have uterine abnormalities or who are prone to
life-threatening complications during pregnancy.
number of modifiable lifestyle factors also contribute to IVF success rates.
- Weight – Being overweight can reduce fertility
and also increase risk of miscarriage, diabetes and premature birth. The male
partners weight also affects the quality of his sperms and hence the IVF
- Smoking, excessive alcohol, drug use,
environmental health is all lifestyle factors that affect IVF success.
A lot goes into
determining your odds of IVF success.
No matter how small
or big each factor is, you should try to optimize all of them for a happy
importance is choosing the right doctor and the right fertility centre for ones
It is also
important to plan multiple full IVF cycles no matter what the first IVF cycle
The couple should
be patient and stress free throughout the treatment, which also helps to
increase the success.